With the aim to move towards a non-toxic environment, European authorities are focusing on emerging concerns (endocrine disruptors, nanoparticles, persistent substances in the environment) and are working to better assess and regulate chemicals with these properties. Science and regulations on these emerging concerns are evolving quickly.
EquiTox is used to maintaining a high level of training, information and expertise on emerging concerns. We can provide technical and regulatory monitoring and help you to anticipate the impact of these advances on your markets and strategies.
1- Endocrine disrupting chemicals (EDCs)
Equitox uses its expertise to evaluate the ED character of your chemicals. We collect and analyze, based on the weight of evidence, all the relevant toxicological and ecotoxicological data to identify the adverse effect(s) and to assess whether the toxicological mode of action is an ED-one.
EquiTox provides its expertise in toxicology and ecotoxicology to develop an integrated testing strategy, using an approach recognized by authorities for EATS (Estrogen-Androgen-Thyroid-Steroidogenic) modes of action, and identify laboratories capable of conducting these complex studies.
2- PBT, vPvB et PMT
3- Case studies
Legal and Technical frameworks are better known with the recent publication of the Delegated Regulations for the BPR (Reg (EU) No 528/2012) and the PPPR (Reg (EC) No 1107/2009) and the subsequent ECHA/EFSA Guidance Documents. Considering this documentation together with the OECD conceptual framework, EQUITOX offers a full range package for Industry.
First of all, one key point is to temper the debate. To that end, experts from EQUITOX provide training based on the science and its legal interpretation. Most of the chemicals currently catching the attention of regulators are characterised by a well-known conventional (eco)toxicological profile. The available historical data has to be correctly interpreted in order to determine if an ED effect can be suspected. Based on this preliminary evaluation, advice on the strategy is provided based on testing and non-testing methods, keeping the main target in mind: an ED is characterised by an ED mode of action with related adverse effects.
This approach has been applied by EQUITOX for both environmental/human health suspected EDs, in the framework of REACH (SVHC, Art. 57(f)) and the BPR.